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KMID : 1144120180080040393
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Biomedical Engineering Letters
2018 Volume.8 No. 4 p.393 ~ p.398
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Promotion of excisional wound repair by a menstrual blood-derived stem cell-seeded decellularized human amniotic membrane
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Farzamfar Saeed
Salehi Majid
Ehterami Arian
Naseri-Nosar Mahdi
Vaez Ahmad
Zarnani Amir Hassan
Sahrapeyma Hamed
Shokri Mohammad-Reza
Aleahmad Mehdi
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Abstract
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This is the first study demonstrating the efficacy of menstrual blood-derived stem cell (MenSC) transplantation via decellularized human amniotic membrane (DAM), for the promotion of skin excisional wound repair. The DAM was seeded with MenSCs at the density of 3?×?104 cells/cm2 and implanted onto a rat’s 1.50?×?1.50 cm2 full-thickness excisional wound defect. The results of wound closure and histopathological examinations demonstrated that the MenSC-seeded DAM could significantly improve the wound healing compared with DAM-treatment. All in all, our data indicated that the MenSCs can be a potential source for cell-based therapies to regenerate skin injuries.
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KEYWORD
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Amniotic membrane, Wound healing, Menstrual blood-derived stem cells
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